After the intervention treatment with doxofylline, total white blood cell count in BALF and the concentrations of IL-8 and TNF-α in BALF and pulmonary tissues in group D were significantly lower, while the concentration of IL-10 was significantly higher, than in group N, indicating that doxofylline could reduce the pulmonary inflammatory response during mechanical ventilation in rats with COPD. The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.