MMP24 and Familial prostate cancer: Furthermore, two of the most significantly affected genes after the loss of REST were CEMIP (cell migration-inducing and hyaluronan-binding protein, KIAA1199) and MMP24 (matrix metalloproteinase-24), which have been shown to be upregulated in many different cancers including breast, colorectal, gastric, and prostate cancer [17–21].