Analysis of the various cancers revealed that several putative REST target genes, including Polo Like Kinase 1 (PLK1), ADAM Metallopeptidase Domain 12 (ADAM12), Troponin T1 (TNNT1), and cell migration-inducing and hyaluronan-binding protein (CEMIP, KIAA1199) were highly dysregulated (Additional file 4). Here, PLK1 is linked to cancer.