PIK3CA and sarcopenia: After GO and KEGG enrichment analyses performed for these MC-sarcopenia targets, we found that proteins affected by MC active components participate in a large number of key sarcopenia related pathogenic signaling pathways, such as endocrine resistance (hsa01522), PI3K-Akt signaling pathway (hsa04151), EGFR tyrosine kinase inhibitor resistance (hsa01521), longevity regulating pathway(hsa04211), etc. (Fig. 3E, Supplementary Table S7).