Although hPD-L1 expression within the tumor was required for intratumoral CD8+ T-cell accumulation, GEN1046 treatment also increased the frequencies of splenic tumor-specific and memory phenotype T cells and proinflammatory and T-cell chemoattractant cytokines in MC38-WT tumor–bearing mice, suggesting that GEN1046 may leverage lymphoid tissue-resident PD-L1–expressing cells to costimulate T cells. The gene discussed is CD8A; the disease is neoplasm.