This would explain the high prevalence of type 2 myocardial infarction200 in those with severe COVID-19 and also the rising incidence of ‘new’ CV diagnoses.7,98,99 Other mechanisms that may contribute include dysregulation of the renin–angiotensin–aldosterone system,6 endothelial dysfunction,186,201,202 renal injury,203 and steroid use.204,205. Here, REN is linked to endothelial dysfunction.