Univariate analysis (P, beta [SD beta]) showed the cytokeratin-18 fragments M30 (P<0.01, 0.84 [0.32]) and M65 (P<0.01, 1.02 [0.37]), IL-6 (P<0.01, 0.4 [0.16]) as well as bilirubin (P<0.001, 0.94 [0.28]) and gamma-glutamyl transferase (GGT) (P<0.001, 0.74 [0.21]) from “routine” biochemistry as strongest predictors of AD in patients with CLD. Here, KRT18 is linked to congenital secretory chloride diarrhea 1.