Chi-square analysis and risk estimation through logistic regression for males in T2DM and control groups showed that allele A of ACE2 G8790A on the X- chromosome was associated with an increased risk of T2DM (OR = 0.263 [95% CI = 0.114–0.604] p = 0.008). The gene discussed is ACE2; the disease is type 2 diabetes mellitus.