SLCO1B1 and myopathy: A guideline for administrating simvastatin for heterozygous (one decrease function allele), e.g., SLCO1B1*1b/*15, *1b/*17 or homozygous variant (two decreased-function allele), e.g., SLCO1B1*15/*15, *15/*17, *17/*17 stated that a lower dose or alternative statin should be prescribed because it implies intermediate/high myopathy risk for heterozygous or homozygous respectively [65].