TLR4 and alcohol dependence: Several of the predicted upstream regulators were also members of the module, suggesting these genes may be particularly important regulators of the blood-brain “immune response” module in CIE-induced alcohol dependence (in decreasing order of significance): Nup107, Rbm5, Tlr4, Ly96, Sf3b1, Aim2, Tnrc6a, Abca1.