Several of the predicted upstream regulators were also module members suggesting these genes may be particularly important regulators of the blood-brain response to CIE-induced alcohol dependence related to protein processing and mitochondrial function / oxidative phosphorylation (in decreasing order of significance): Bnip3l, Gpx1, Irf7, Adipor1, Uros, Mafg. The gene discussed is GPX1; the disease is alcohol dependence.