IFNA1 and infection: Dynamic gene signatures from the IFN-I signaling pathway and mitochondrial ATP synthesis–coupled electron transport were shown using traditional heatmaps in Supplemental Figure 2, B and C. The temporal analysis of this nonhuman primate data set not only highlights the rapidity of IFN signaling activation, but also underscores that this initial burst of immune activation is transient and is followed by a gradual downregulation of the antiviral IFN responses during the first week following infection.