In contrast, while the significant positive correlation between SAP18 and SNCA was maintained in PD (r = 0.77, p = 6.51 × 10−04), the correlations of both ZNHIT1 (r = 0.13, not significant (n.s.)) and HDAC5 (r = 0.28, n.s.)with SNCA was lost in PD SN samples, with the greatest change in r seen in SNCA-ZNHIT1 (Fig. 1E). Here, ZNHIT1 is linked to Parkinson disease.