The assay of an analyte that encompasses LDL, TRL/remnants, and Lp(a) (Fig. 1), all of which have strong genetic evidence to support their causal relationship to ASCVD [2, 3, 4•, 5••, 64, 65], is attractive and guidelines provide subsidiary goals for these biomarkers [11•] (a fuller assessment of the role of Lp(a) in ASCVD and the measurement issues involved in quantifying accurately this lipoprotein species has been the subject of recent reviews and innovations [26•, 42, 52, 66, 67]). The gene discussed is LPA; the disease is atherosclerosis.