In fact, spontaneous upregulation of VEGF at physiologically limited levels by ischemia leads to sprouting (Al Haj Zen et al. 2010), whereas its over-expression at significantly higher and therapeutic levels, which saturate the scarce matrix between muscle fibers and abrogate local gradients, induces angiogenesis by intussusception (Gianni-Barrera et al. 2013). Here, VEGFA is linked to ischemia.