Although the association of high HSP90 levels with systemic disease in cancer has been broadly reported (Pick et al, 2007; Gallegos Ruiz et al, 2008; McCarthy et al, 2008; Su et al, 2016; Dimas et al, 2018), whether this association involves any specific step of the metastatic cascade had not been addressed. Here, HSP90AA1 is linked to cancer.