CHEK2 and neoplasm: The highest frequency of CHEK2 pathogenic variants in our study was similarly observed among individuals with a history of both BCa and TCa, which may further suggest the role of CHEK2 as a potential cancer predisposition gene associated with both tumor types, pointing to a possible role for TCa in the ascertainment of individuals with germline CHEK2 pathogenic variants, as noted for PTEN pathogenic variants in this study.