Interestingly, analysis of the p53-only altered tumors demonstrated signatures were more consistent with human UPS (Tsumura et al., 2006; Doyle et al., 2010), while the knock-in of the mutant K-Ras not only significantly accelerates tumor formation, but also drives the molecular signatures that highly correspond to human FP-RMS and FN-RMS. This evidence concerns the gene TP53 and neoplasm.