Regarding the pathological findings of the non‐tumorous liver, liver cirrhosis was significantly more frequently observed in HCV‐SVR‐DAA than in HCV‐SVR‐IFN (p = 0.006), indicating that HCC can occur on a background of severe fibrotic liver after HCV‐SVR by DAA, and that HCC can occur on a normal liver background after HCV‐SVR by IFN. Here, IFNA1 is linked to hepatocellular carcinoma.