The reverse transcription qPCR (RT‐qPCR) results showed that the relative mRNA levels of TFAM and nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 6 (ND6) in the skin tissue of diabetic mice were downregulated and the levels in the DM + IMQ group decreased significantly (Figure 4C), suggesting that diabetes combined with psoriasis may aggravate mitochondrial oxidative damage. Here, MT-ND6 is linked to diabetes mellitus.