Western blot analysis showed lower mitochondrial transcription factor A (TFAM) and oxidative phosphorylation of oxidative phosphorylation system (OXPHOS) proteins (CV‐ATP5A, CIII‐UQCRC2, CIV‐MTCO1, CII‐SDHB and CI‐NDUFB8) in the skin tissue of diabetic mice, especially in the DM + IMQ group (Figure 4B). The gene discussed is MT-CO1; the disease is diabetes mellitus.