Considering the ability of dTMS to modulate directly or indirectly (via cortical excitability) the ANS [21, 22], to promote neuro-hormonal peptides release, as the β-endorphin [23], and to potentially affect the leptin system by promoting weight loss (many hypothalamic neurons involved in regulating thermogenesis are also leptin sensitive) [24, 25], we hypothesized a potential role of dTMS in affecting thermoregulation in obesity, and in reversing obesity-induced alterations in body temperature. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.