Among the two genetic variants for LDL-C variability (rs2266788 and rs662799), the SNP rs2266788 in APOA5 was significantly associated with increased risks of having CACS ≥400 (adjusted odds ratio [OR] 2.196, 95% confidence interval [CI] 1.098–4.394, p = 0.0262) and coronary stenosis ≥70% (adjusted OR 3.083, 95% CI 1.18–8.639, p = 0.0323). This evidence concerns the gene APOA5 and coronary stenosis.