So far, dysregulation of the CMTM6 gene has been reported in many cancers, including head and neck squamous cell carcinoma (Chen et al., 2020), metastatic melanoma (Martinez-Morilla et al., 2020), non–small cell lung cancer (Zugazagoitia et al., 2019), and triple-negative breast cancer (Tian et al., 2021). The gene discussed is CMTM6; the disease is metastatic melanoma.