Most previous studies have shown the tumorigenicity of CMTM6 in the development and progression of cancer (Guan et al., 2018; Chen et al., 2020; Zheng et al., 2020); there are few studies that discussed the tumor-suppressive effect of CMTM6 (Mamessier et al., 2018). The gene discussed is CMTM6; the disease is neoplasm.