Adverse redox signaling of and by microglia (immune cells of the brain) associated with microglial dysregulation constitutes a hallmark of various neurological disease phenotypes leading to neuronal damage/loss and amyloid deposition accompanied by decreased cerebral •NO bioavailability via NOX-2 activation and uncoupling of nNOS and subsequent cerebral vascular endothelial dysfunction (Hahad et al., 2021). The gene discussed is CYBB; the disease is nervous system disorder.