Adverse redox signaling of and by microglia (immune cells of the brain) associated with microglial dysregulation constitutes a hallmark of various neurological disease phenotypes leading to neuronal damage/loss and amyloid deposition accompanied by decreased cerebral •NO bioavailability via NOX-2 activation and uncoupling of nNOS and subsequent cerebral vascular endothelial dysfunction (Hahad et al., 2021). This evidence concerns the gene NOS1 and nervous system disorder.