Our current concept of cardiovascular effects caused by aircraft noise includes that endothelial dysfunction, which is established already after one night of aircraft noise, is largely triggered by a noise-dependent release of stress hormones, vasoconstrictors such as adrenaline, corticosterone (cortisol in humans) and by an activation of the of the renin-angiotensin-aldosterone system (RAAS) (Munzel et al., 2017) as well as a hypersensitivity of the vasculature to vasoconstrictors (Munzel et al., 2017). Here, REN is linked to endothelial dysfunction.