Through these reports the autophagic machinery in NAFLD has been well documented and includes classic autophagic markers such as ATG5, ATG7, BECLIN-1, p62/SQSTM1, LC3-II/I, and S6K1(Singh et al., 2009; Yang et al., 2010; Gonzalez-Rodriguez et al., 2014). This evidence concerns the gene SQSTM1 and metabolic dysfunction-associated steatotic liver disease.