Finally Gonzalez-Rodriguez et al. studied liver samples from healthy control, NAFL, and NASH patients and established that patients with NASH had significantly less autophagy than both other groups as seen by their increased p62 protein levels, increased phopspho-mTOR, increased phospho-S6K1, and decreased mRNA levels of Beclin-1 (Gonzalez-Rodriguez et al., 2014). Here, BECN1 is linked to metabolic dysfunction-associated steatohepatitis.