STUB1 and alcoholic liver cirrhosis: Analyses of RNAseq from patients with alcoholic hepatitis showed increased expression of numerous ERAD genes, including those involved in CYP2E1 turnover (AMFR and VCP), though this reversed in patients with alcoholic cirrhosis, who displayed reduced expression of Stub1/CHIP (Table 2) (Bourd-Boittin et al., 2011; Caillot et al., 2009a; Trepo et al., 2018; Hyun et al., 2020; Affo et al., 2013).