FASN and fibrosis: In fact, the phenomenon of lipid metabolism disorder in IPF patients has also been verified in animal models of fibrosis; for example, Chung et al. (2019) found the loss of AEC2 cell-specific FASN in bleomycin-induced pulmonary fibrosis in mice and the loss of lipid synthesis in AEC2 cells during mitochondrial injury could aggravate pulmonary fibrosis.