In our study, a great number of immune factors were altered in IPF patients, including upregulation of CXCL5, CXCL13, CXCL14, IL5RA, and TNFRSF19 and downregulation of CSF3R, S100A8, S100A9, and S100A12. Here, CSF3R is linked to idiopathic pulmonary fibrosis.