In this study we put together our latest cases with the same clinical pattern, namely edema due to hypoproteinemia/hypoalbuminemia from enteral loss of proteins, confirmed by high values of α1 antitrypsin (α1AT) in the stools and no other pathology explaining the hypoproteinemia including normal kidney and liver function parameters, and observed them further, with the aim of establishing a distinct clinical entity. This evidence concerns the gene SERPINA1 and Hypoalbuminemia.