We propose the term “food-protein induced protein-losing enteropathy” (FPIPLE) to describe this clinical entity, which would include infants with mixed IgE and non-IgE food allergy, with poor weight gain and/or edema due to hypoproteinemia/hypoalbuminemia by enteral loosing of proteins, confirmed by high values of alpha 1-antitrypsin (α1AT) in stools and no other pathology explaining the hypoproteinemia including normal kidney and liver function parameters. Here, SERPINA1 is linked to Protein-losing enteropathy.