As a stress-induced inflammatory signaling pathway, signal transducers and activators of transcription 3 (STAT3) play an essential role in regulating various biological behaviors of a normal organism, such as immune response, tissue repair, cell growth, etc. STAT3 is an indispensable key molecule in the tumorigenesis and tumor-associated inflammation process, which is promoted by chronic inflammation and abnormal activation of STAT3. This evidence concerns the gene STAT3 and neoplasm.