Using 246 candidate biomarkers obtained from the network and according to the processes mentioned above, we identified 5 prognostic risk markers for BLCA from the univariate COX proportional hazard regression model (Table 1), including ELF3, FASLG, PRKCZ, HIST3H3, BCL10, as well as 4 clinical factors (Table 2), including age, N stage, T stage, and pathological stage. This evidence concerns the gene H3-4 and bladder transitional cell carcinoma.