Tran et al. have demosrated GCH1 has an obvious ascending trend with grade increase, and plays a role in promoting progression in GBM (Tran et al., 2018), suggesting that GCH1 may play a more important role in high-grade glioma, while its role in low-grade glioma needs further discussion in the future. The gene discussed is GCH1; the disease is glioblastoma.