IDH1 and central nervous system cancer: Additionally, the prediction accuracy of FRGPI was highly stable in different clinical character groups, including <45 and >45-year age group, LGG (grade I–II gliomas are classified as LGG in the TCGA database) and GBM (grade IV gliomas) groups, IDH1-WT and IDH1-Mut groups, 1p19q non-codel group, except in 1p19q codel group, in TCGA training set (Supplementary Figures 5A–H), and these results were verified again in the CGGA validation set (Supplementary Figures 5I–P).