CD274 and cancer: For example, PD-L1 expression and PD-1 checkpoint pathway, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, B cell receptor signaling pathway, and Leukocyte transendothelial migration, all were enriched with increased PKCs expression depending on the cancer type.