Ren et al. (2015) discovered that the downregulation of MYBL2 was able to suppress cell proliferation, regulate the cell cycle, and induce apoptosis, which may be involved in mediating aggressive CRC biology. TGFB1, the downstream protein of the transforming growth factor-β signaling, contributes to their metastatic potential and stromal cell independence directly in CRC cells (Chiavarina et al., 2021). Researchers identified SLC35D3 as a new biomarker with prognostic value (Olsson et al., 2020). This evidence concerns the gene TGFB1 and colorectal carcinoma.