Screening of tumor suppressor genes in metastatic colorectal cancer (CRC) has revealed that methyl-binding protein 1 (MBD1) gene, compared with other genes that were screened for methylation levels, had the most downregulated messenger RNA (mRNA) expression and upregulated methylation levels in advanced CRC (Parry and Clarke, 2011). The gene discussed is MBD1; the disease is colorectal carcinoma.