EX527, a Sirt-1 inhibitor, can inhibit the growth of glioma by activating the p53 signaling pathway, which was reported to be related to ferroptosis in lung cancer, and HOXA-AS2 may be associated with the p53 gene in hepatocellular carcinoma (Mao et al., 2018; Lu J. et al., 2020; Lu Q. et al., 2020; Wang et al., 2020; Zhao et al., 2020). The gene discussed is TP53; the disease is central nervous system cancer.