Also, the integrin-mediated signaling transduction pathway of focal adhesion kinase (FAK) was identified by the Gene Expression Omnibus (GEO) database and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis as the pathway where the significantly different ncRNAs between the imatinib treated GIST patients with and without resistance were enrich in (Zhang et al., 2018). The gene discussed is PTK2; the disease is gastrointestinal stromal tumor.