Studies by Lui et al. revealed that overexpression of miRNA-125a-5p suppressed the expression of PTPN18 and increased the phosphorylation of FAK, thus contributing to the re-sensitization of GIST cells towards imatinib (Akcakaya et al., 2014; Huang et al., 2018). This evidence concerns the gene PTPN18 and gastrointestinal stromal tumor.