It was shown in a recent report that Rothia mucilaginosa could inhibit host NF-κB pathway activation in a human lung epithelial cell line (Rigauts et al., 2021), and another commensal Prevotella histicola was reported to be able to induce alternative NF-κB activation in CF bronchial epithelial cells (Bertelsen et al., 2020). This evidence concerns the gene NFKB1 and cystic fibrosis.