The aberrantly upregulated expression of the gene was observed in various human cancers, such as prostate cancer and bladder cancer (Ueno et al., 2012; Formosa et al., 2014).The upregulation of FZD4 expression was associated with tumor proliferation, migration and invasion, which was mediated by Wnt/β-catenin pathway (Yang et al., 2018; Chen et al., 2019). This evidence concerns the gene FZD4 and urinary bladder cancer.