Gene set enrichment analysis according to TLR using the REACTOME and KEGG databases demonstrated upregulated glucose metabolism, including glycolysis and hypoxia-inducible factor-1 (HIF-1) signaling pathway upregulation, and downregulated lipid metabolism, including fatty acid metabolism and peroxisome proliferator-activated receptor (PPAR) signaling pathway downregulation, in HCC with high TLR phenotype (Figure 1). Here, PPARA is linked to hepatocellular carcinoma.