For this, we investigated normal human epidermal keratinocytes (NHEK) as well as keratinocytes from our isogenic human skin cancer model (15); the HaCaT cells as well as their Hras-containing tumorigenic variants, the benign tumorigenic HrasA5 cells and the malignant tumorigenic HrasII4 cells. The gene discussed is HRAS; the disease is skin neoplasm.