It is intriguing that we found that tumor metastasis related genes, including MMP14, ELK3, BLM ZKSCAN1, FRS2, CANT1, CCN2, SOX18, CDK1, TGFBR1, Foxc2, and MAPK14, were significantly downregulated in ACADL-overexpressed cells (Figure 5A). This evidence concerns the gene FRS2 and neoplasm.