Kaplan-Meier survival analysis indicated that the hypermethylation of TRPV1 in LAML and BLCA, TRPV4 in SARC and UCEC, TRPV5 in BLCA, TRPV2 in ACC, and SARC cancers was associated with a poor prognosis in most tumors. The gene discussed is TRPV5; the disease is bladder transitional cell carcinoma.