As shown in Table 1, the results adjusted based on tumor purity revealed a significant correlation between MECOM and markers of monocyte (CD86), M1 macrophage (NOS2), M2 macrophage (COX2) neutrophils (CD66b, CCR7), NK (KIR2DL4), DC (HLA-DPB1, CD1C), Th1 (STAT1, IFNG), Th2 (STAT6, STAT5A), Tfh (BCL6), Th17 (STAT3), Treg (STAT5B), and T-cell exhaustion (PD-1, LAG3, HAVCR2, GZMB) in LUAD. This evidence concerns the gene NOS2 and neoplasm.