According to several studies, NOLC1 localized in the nucleolus interacts with telomeric repeat-binding factor 2 (TRF2), and the overexpression of NOLC1 inhibits cell proliferation by inducing apoptosis and cell cycle arrest in hepatocellular carcinoma (14, 43). The gene discussed is NOLC1; the disease is hepatocellular carcinoma.