CDH1 and neoplasm: Produce H2S, invades the host cell, generating proinflammatory cytokines through its surface virulence factor, FadA, by binding to E-cadherin. Although E-cadherin is a tumor suppressor, its tumor suppressor activity is inhibited by binding with FadA. Also, the binding of the FadA adhesion molecule and E-cadherin results in activating the β-catenin signaling pathway, inducing pro-oncogenic pathways, also leading to tumorigenesis.