The N-glycosylation reaction catalyzed by OST had been implicated in cell-to-cell communication, signal transduction, trafficking, folding, and the degradation of proteins (Ohtsubo and Marth, 2006; Harada et al., 2015; Mikolajczyk et al., 2020) and was involved in the mechanism of tumor immune escape in the tumor microenvironment (Hsu et al., 2018). The gene discussed is DDOST; the disease is neoplasm.