CASP1 and acute respiratory distress syndrome: In the PEITC (pre) and PEITC (post) groups, the expression level of NLRP3 was downregulated, and the activation and cleavage of CASP1 and GSDMD were inhibited, indicating that PEITC can prevent ConA-induced ALI model mouse hepatocyte pyroptosis (Figures 3D, E).