For instance, a previous study showed that the overall survival rate of the high exosomal PD-L1 group was significantly lower than the low exosomal PD-L1 group, exosomal PD-L1 in GC patients was negatively associated with CD4 T cell and CD8 T-cell count, indicating that exosomal PD-L1 was associated with the immunosuppressive status of GC patients (103). The gene discussed is CD8A; the disease is gastric cancer.