At functional level, we showed an impaired secretion of TNFα by both CD117- ILCs and CD117+ ILCs from melanoma patients, as reported in blood tumors (17, 18), and the capability of Nivolumab to enhance the secretion of IL-13 and TNFα by ILC2s and CD117+ ILCs, respectively. The gene discussed is TNF; the disease is hematopoietic and lymphoid system neoplasm.