First, Trp depletion induced by IDO1 in the TME suppress the mammalian target of rapamycin complex (mTORC) pathway and activates the stress response kinase general control over nonderepressible 2 (GCN2) in tumor-infiltrating T cells, leading to their anergy and apoptosis (32–34). The gene discussed is EIF2AK4; the disease is neoplasm.