Concerning neoadjuvant ICIs plus chemotherapy, the most common all-grade irAEs were anemia (37%; 95% CI, 14%-59%), diarrhea (32%; 95% CI, 24%-40%), and ALT increased (25%; 95% CI, 22%-28%) (Figure 3C), and the most common high-grade irAEs were anemia (16%; 95% CI, 14%-18%), AST increased (5%; 95% CI, 2%-9%), and ALT increased (5%; 95% CI, 4%-7%) (Figure 3D). This evidence concerns the gene GPT and anemia.