LE was the most frequent syndrome in various antibodies including anti-amphiphysin, anti-GABABR, anti-NMDAR, and anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antibodies, corresponding to SCD/RPCS in anti-Yo and anti-CV2 antibodies, LEMS in anti-SOX1 and anti-VGCC antibodies, and peripheral neuropathy in anti-CV2 and anti-Ma2 antibodies. The gene discussed is CDR2; the disease is Schnyder corneal dystrophy.