Six cases encountered postoperative pituitary–thyroid axis hypofunction, of which 3 cases improved within 1–3 months after surgery, and 3 patients still needed extra hormone replacement treatment; patients with pituitary–adrenal axis dysfunction was found in 7 cases, and among them, 3 cases improved to varying degrees, but 4 cases still needed extra oral drug therapy; in addition, 2 cases had hypogonadism and 4 cases had decreased growth hormone. This evidence concerns the gene GH1 and hypogonadism.