The AUC of miR-134 was 0.834 (95% confidence interval, 0.88–0.97); and the level of secreted miR-134 was correlated with the National Institutes of Health Stroke Scale (NIHSS) score and infarct volume, and positively correlated with serum interleukin-6 (IL-6), high sensitivity C-reactive protein (hsCRP), and a poor prognosis for stroke. The gene discussed is IL6; the disease is Stroke.